Antibacterial and cytotoxic bioactivity of marine Actinobacteria from Loreto Bay National Park, Mexico

Autores

  • Faviola Cardoso-Martínez Facultad de Ciencias Marinas, Universidad Autónoma de Baja California, km 103 Carretera Tijuana- Ensenada, Baja California, 22830, México
  • Amayaly Becerril-Espinosa Facultad de Ciencias Marinas, Universidad Autónoma de Baja California, km 103 Carretera Tijuana- Ensenada, Baja California, 22830, México
  • Celso Barrila-Ortíz Facultad de Ciencias Marinas, Universidad Autónoma de Baja California, km 103 Carretera Tijuana- Ensenada, Baja California, 22830, México
  • Mónica Torres-Beltrán Department of Microbiology & Immunology, University of British Columbia, Life Sciences Centre, 2350 Health Sciences Mall, Vancouver, BC, V6T 1Z3 Canada
  • Héctor Ocampo-Alvarez Departamento de Hidrobiología, Universidad Autónoma Metropolitana Iztapalapa, Av. San Rafael Atlixco No. 186, Col. Vicentina, Iztapalapa, D.F. México 09340, México
  • Ana M. Iñiguez-Martínez Facultad de Ciencias Marinas, Universidad Autónoma de Baja California, km 103 Carretera Tijuana- Ensenada, Baja California, 22830, México
  • Irma E. Soria-Mercado Facultad de Ciencias Marinas, Universidad Autónoma de Baja California, km 103 Carretera Tijuana- Ensenada, Baja California, 22830, México

Palavras-chave:

Antibiotic activity, Gulf of California, Loreto Bay, Marine Actinobacteria, Salinispora

Resumo

Production of bioactive compounds is intimately linked to the ecology of the producing organisms. Taking this into account, the objective of this study was to evaluate the bioactive properties of isolated Actinobacteria from sea sediments of a high biodiversity zone; under the hypothesis that the ecological characteristics of this site stimulate the presence of unique and bioactive strains that can be screened for new compounds with antibiotic and anticancer properties. The elected zone was the Loreto Bay National Park in the Gulf of California Mexico, a protected natural area, with high diversity of flora and fauna. The bioactive properties of strains from this area were different to that reported elsewhere. The cytotoxic activity tested by in vitro assays was present in 40% of the tested strains and antibacterial activity in 71% of all evaluated strains. This percentage of active strains resulted unusually high when it was compared to similar studies from other regions of the world. This supports the hypothesis of the influence of ecological characteristics of the area of study on the presence of unique and bioactive Actinobacteria. Thereby, the Actinobacteria community found in Loreto Bay, in the Gulf of California, which presented unusual bioactive properties, represents a potential source for obtaining novel compounds with antibacterial and anticancer activity.

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Cardoso-Martínez, F., Becerril-Espinosa, A., Barrila-Ortíz, C., Torres-Beltrán, M., Ocampo-Alvarez, H., Iñiguez-Martínez, A. M., & Soria-Mercado, I. E. (2016). Antibacterial and cytotoxic bioactivity of marine Actinobacteria from Loreto Bay National Park, Mexico. HIDROBIOLÓGICA, 25(2), 223–229. Recuperado de https://hidrobiologica.izt.uam.mx/index.php/revHidro/article/view/479

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